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The study linking Celebrex to heart risks was sponsored by the National Cancer Institute, which was studying whether high doses of Celebrex could prevent colon growths that can lead to cancer. The research showed that people taking 800 milligrams of Celebrex had 3.4 times more risk of cardiovascular events such as heart attacks compared with those taking a placebo, the FDA said. For patients in the trial taking 400 milligrams daily, the risk was 2.5 times greater. Celebrex's U.S. label tells people to take 100 milligrams to 200 milligrams daily for the most common form of arthritis, and 200 milligrams to 400 milligrams a day for rheumatoid arthritis.